May 28, 2022
Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study.

Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study.

OBJECTIVE
Within the conventional system of medication in India Ashwagandha powder and Sidh Makardhwaj have been used for the therapy of rheumatoid arthritis. Nonetheless, security and efficacy of this therapy haven’t been evaluated. Due to this fact, the current examine was carried out to guage the efficacy and security of Ayurvedic therapy (Ashwagandha powder and Sidh Makardhwaj) in sufferers with rheumatoid arthritis.
METHODS
100 and twenty 5 sufferers with joint ache have been screened at an Ayurvedic hospital in New Delhi, India. Eighty six sufferers happy inclusion standards and have been included within the examine. Detailed medical historical past and bodily examination have been recorded. Sufferers took 5g of Ashwagandha powder twice a day for 3 weeks with lukewarm water or milk. Sidh Makardhwaj (100 mg) with honey was administered day by day for the following 4 weeks. The observe up of sufferers was carried out each two weeks. The first efficacy finish level was primarily based on American Faculty of Rheumatology (ACR) 20 response. Secondary finish factors have been ACR50, ACR70 responses, change from baseline in illness exercise rating (DAS) 28 rating and ACR parameters. Security assessments have been hepatic perform [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin and ß2 microglobulin], renal perform (urea and creatinine and NGAL) exams and urine mercury degree.
RESULTS
The examine was accomplished by 90.7 per cent (78/86) sufferers. Sufferers with average and excessive illness exercise have been 57.7 per cent (45/78) and 42.three per cent (33/78), respectively. All sufferers have been examined optimistic for rheumatoid issue and elevated ESR degree. Ashwagandha and Sidh Makardhwaj therapy decreased RA issue. A major change in post-treatment scores of tender joint counts, swollen joint counts, doctor international evaluation rating, affected person international evaluation rating, ache evaluation rating, affected person self assessed incapacity index rating and ESR degree have been noticed as in comparison with baseline scores. ACR20 response was noticed in 56.four per cent (44/78) sufferers (American Faculty of Rheumatology standards) and average response in 39.74 per cent (31/78) sufferers [European League Against Rheumatism (EULAR) criteria]. Ayurvedic therapy for seven weeks in rheumatoid arthritis sufferers confirmed regular kidney and liver perform exams. Nonetheless, elevated urinary mercury ranges have been was noticed after therapy.
CONCLUSIONS
The findings of the current examine counsel that this Ayurvedic therapy (Ashwagandha powder and Sidh Makardhwaj) has a possible for use for the therapy of rheumatoid arthritis. Nonetheless, resulting from small pattern measurement, quick length, non randomization and lack of a management group as examine limitations, additional research should be achieved to verify these findings.

Ayurpharmacoepidemiology en Path to Safeguarding Security and Efficacy of Ayurvedic Medication in International Outlook.

Ayurpharmacoepidemiology is a brand new area developed by synergy of the fields of scientific pharmacology, epidemiology, and ayurveda. It should use the consequences of ayurvedic medicinal merchandise on giant populations to explain and analyze the practices, consider the protection and efficacy, and perform medicoeconomic evaluations. Good pharmacoepidemiology practices in ayurveda is projected to help with problems with ayurpharmacoepidemiologic analysis.
The embraced good pharmacoepidemiology practices guideline on this viewpoint will have the ability to present invaluable proof in regards to the well being results of ayurvedic herbs/medication and think about totally different fields like pharmacovigilance, pharmacoeconomics, and drug discovery with ayurvedic reverse pharmacology strategy, additionally cross out vital knowledge for additional primary sciences examine in ayurveda biology, ayurgenomics, ayurnutrigenomics, and programs biology. A number of unanswered questions on ayurvedic drug use and knowledgeable interventions or insurance policies that may be addressed by informatics database, which is able to ultimately exhibit the credibility and rationality of ayurceuticals sooner or later.
 Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study.
Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study.

[Computer evaluation of hidden potential of phytochemicals of medicinal plants of the traditional Indian ayurvedic medicine].

Applicability of our laptop applications PASS and PharmaExpert to prediction of organic exercise spectra of quite complicated and structurally numerous phytocomponents of medicinal crops, each individually and in mixtures has been evaluated. The online-resource on phytochemicals of 50 medicinal crops utilized in Ayurveda was created for the examine of hidden therapeutic potential of Conventional Indian Drugs (TIM) . It incorporates info on 50 medicinal crops, their utilizing in TIM and their pharmacology actions, additionally as 1906 phytocomponents.
PASS coaching set was up to date by addition of details about 946 pure compounds; then the coaching process and validation have been carried out, to estimate the standard of PASS prediction. It was proven that the distinction between the typical accuracy of prediction obtained in leave-5%-out cross-validation (94,467%) and in leave-one-out cross-validation (94,605%) may be very small. These outcomes confirmed excessive predictive capability of this system. Outcomes of organic exercise spectra prediction for all phytocomponents included in our database are in good correspondence with the experimental knowledge. Extra sorts of organic exercise predicted with excessive chance present the details about most promising instructions of additional research.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Mu-48Tests 48 Tests
EUR 489

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Mu-96Tests 96 Tests
EUR 677

anti-LIF

YF-PA12952 50 ug
EUR 363
Description: Mouse polyclonal to LIF

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-b-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-b-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-c-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Canine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-c-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Canine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Hu-48T 48T
EUR 380
Description: A sandwich quantitative ELISA assay kit for detection of Human Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Hu-96T 96T
EUR 485
Description: A sandwich quantitative ELISA assay kit for detection of Human Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-p-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-p-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-b-48Tests 48 Tests
EUR 580

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-b-96Tests 96 Tests
EUR 807

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-c-48Tests 48 Tests
EUR 557

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-c-96Tests 96 Tests
EUR 774

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Hu-48Tests 48 Tests
EUR 383

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Hu-96Tests 96 Tests
EUR 525

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-p-48Tests 48 Tests
EUR 580

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-p-96Tests 96 Tests
EUR 807

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Ra-48Tests 48 Tests
EUR 534

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Ra-96Tests 96 Tests
EUR 742

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-b-48Tests 48 Tests
EUR 555

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-b-96Tests 96 Tests
EUR 771

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-c-48Tests 48 Tests
EUR 533

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-c-96Tests 96 Tests
EUR 740

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Hu-48Tests 48 Tests
EUR 367

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Hu-96Tests 96 Tests
EUR 502

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-p-48Tests 48 Tests
EUR 555

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-p-96Tests 96 Tests
EUR 771

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Ra-48Tests 48 Tests
EUR 511

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Ra-96Tests 96 Tests
EUR 709

Anti-LIF Antibody

PA1562 100ug/vial
EUR 294

Anti-LIF Antibody

PB9036 100ug/vial
EUR 334

Anti-LIF Antibody

A01400 100ug/vial
EUR 294

Anti-LIF antibody

STJ96472 200 µl
EUR 197
Description: Rabbit polyclonal to LIF.

Anti-LIF antibody

STJ73631 100 µg
EUR 359

Anti-LIF antibody

STJ29846 100 µl
EUR 277
Description: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

anti- LIF antibody

FNab09804 100µg
EUR 548.75
Description: Antibody raised against LIF

anti- LIF antibody

LSMab09804 100 ug
EUR 386

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

LIF, Mouse

HY-P7084 50ug
EUR 533

LIF, mouse

MO16102 100 ug
EUR 675

Anti-LIF (aa28-39) antibody

STJ72919 100 µg
EUR 359

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Mouse LIF ELISA Kit

EML0014 96Tests
EUR 521

Mouse LIF shRNA Plasmid

20-abx971321
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Recombinant Mouse LIF Protein

R01400-1 100ug/vial
EUR 294

LIF, Human

HY-P7049 10ug
EUR 1600

LIF siRNA

20-abx922546
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

LIF siRNA

20-abx922547
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

LIF Antibody

25283-100ul 100ul
EUR 390

LIF Antibody

36950-100ul 100ul
EUR 252

LIF, human

MO16101 100 ug
EUR 688

LIF Antibody

1-CSB-PA198481
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:25-1:100

LIF Antibody

1-CSB-PA012928ESR2HU
  • EUR 222.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: ELISA

LIF Antibody

1-CSB-PA004761
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

rHu LIF

AK9977-0005 5µg Ask for price

rHu LIF

AK9977-0025 25µg Ask for price

rHu LIF

AK9977-0100 100µg Ask for price

rHu LIF

AK9977-1000 1mg Ask for price

LIF Antibody

5216-100
EUR 316

LIF Antibody

5216-30T
EUR 146

LIF antibody

PAab09804 100 ug
EUR 386

LIF antibody

70R-6230 50 ug
EUR 467
Description: Rabbit polyclonal LIF antibody

LIF protein

30R-2771 10 ug
EUR 369
Description: Purified recombinant Human LIF protein

LIF protein

30R-2772 10 ug
EUR 489
Description: Purified recombinant Mouse LIF protein

LIF antibody

70R-12299 100 ug
EUR 403
Description: Rabbit polyclonal LIF antibody

LIF antibody

70R-14100 100 ug
EUR 322
Description: Affinity purified Rabbit polyclonal LIF antibody

LIF antibody

70R-51295 100 ul
EUR 244
Description: Purified Polyclonal LIF antibody

LIF Peptide

6245P 0.05 mg
EUR 164.75
Description: (IN) LIF peptide

LIF Peptide

43-200P 0.1 mg
EUR 338

LIF Antibody

6245-002mg 0.02 mg
EUR 171.82
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF Antibody

6245-01mg 0.1 mg
EUR 436.42
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

Mouse LIF PicoKine ELISA Kit

EK0580 96 wells
EUR 425
Description: For quantitative detection of mouse LIF in cell culture supernates, serum and plasma (heparin, EDTA).

LIF ELISA Kit (Mouse) (OKBB00760)

OKBB00760 96 Wells
EUR 505
Description: Description of target: Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

LIF ELISA Kit (Mouse) (OKEH04045)

OKEH04045 96 Wells
EUR 544
Description: Description of target: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.039 ng/mL

ELISA kit for Mouse LIF

EK5250 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse LIF in samples from serum, plasma, tissue homogenates and other biological fluids.

LIF, Mouse Recombinant , 1MIU/ml

L4500-001 1ml
EUR 339

LIF, Mouse Recombinant , 1MIU/ml

L4500-005 5x1ml
EUR 1193

LIF, Mouse Recombinant , 10MIU/ml

L4501-001 1ml
EUR 1454

Leukemia Inhibitory Factor (LIF), mouse

PR16102 5 ug
EUR 435

Human CellExp? LIF, mouse recombinant

7268-10
EUR 370

Lif ORF Vector (Mouse) (pORF)

ORF049145 1.0 ug DNA
EUR 506

Lif ORF Vector (Mouse) (pORF)

ORF049146 1.0 ug DNA
EUR 506

LIF Polyclonal Antibody

ES3837-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against LIF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

LIF Polyclonal Antibody

ES3837-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against LIF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

LIF Polyclonal Antibody

ABP52838-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF

LIF Polyclonal Antibody

ABP52838-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF

LIF Polyclonal Antibody

ABP52838-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF

LIF Blocking Peptide

20-abx064170
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

LIF Rabbit pAb

A1288-100ul 100 ul
EUR 308

LIF Rabbit pAb

A1288-200ul 200 ul
EUR 459
The evaluation of prediction outcomes of units of phytocomponents in every of 50 medicinal crops was made by PharmaExpert software program. Based mostly on this evaluation, we discovered that the mix of phytocomponents from Passiflora incarnata might exhibit nootropic, anticonvulsant and antidepressant results. Experiments carried out in mice fashions confirmed the expected results of Passiflora incarnata extracts.

Leave a Reply

Your email address will not be published.