October 20, 2021

Metabolite profiling and evaluation of CYP450 interaction potential of ‘Trimada’- An Ayurvedic formulation

Ethnopharmacological relevance: Trimada is well-known polyherbal Ayurvedic formulation utilized in Indian Conventional drugs since historic occasions. It consisted of three inebriant herbs together with “Chitraka” (Plumbago zeylanica Linn. Household- Plumabaginaceae), “Musta” (Cyperus rotundus Linn. Household- Cyperaceae) and Vidanga (Embelia ribes Burm. F. Household- Myrsinaceae) in equal ratios as talked about in Ayurveda. Trimada is historically used to extend the functioning of the digestive system and metabolism. Together with these, it additionally assists within the discount of ldl cholesterol in addition to reduces abdomen aches and chest ache.
Purpose of the examine: This examine is aimed to determine the metabolites current on this polyherbal formulation. Additional, the cytotoxicity and interplay potential of the formulation and particular person herbs with Cytochrome P450 isozymes (CYP3A4, 2D6, 2C9, 1A2) was evaluated by MTT assay and CYP450 enzyme inhibition. The focus of heavy metals was additionally decided.
Materials and strategies: Extremely-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS) evaluation was carried out to detect and determine the phytoconstituents within the formulation. Cytotoxicity of the formulation was evaluated by MTT assay. CYP450 enzyme interplay potential of the person herbs and the Trimada formulation was carried out by way of CYP-CO assay and fluorometric excessive throughput screening (HTS) assay for particular person isozymes. The content material of heavy metallic within the formulation was quantified by Atomic Absorption Spectroscopy.
Outcomes: Trimada formulation exhibited decrease cytotoxicity to human liver carcinoma cell line (HepG2). CYP-CO assay revealed that the interplay potential of particular person herbs and Trimada on the liver microsomes was discovered to be lesser than the usual inhibitor ketoconazole. Particular person herbs and Trimada formulation displayed increased IC50 values than the respective commonplace inhibitors within the fluorimetric assay. UPLC-QTOF-MS evaluation confirmed the presence of plenty of lively phytoconstituents together with sesquiterpenes, phenolic acids, benzoquinones, triterpenes and flavonoids. The heavy metallic focus within the conventional medicinal natural formulation was discovered inside the accredited restrict.
Conclusions: This examine steered that the person herbs and Trimada formulation exhibited low cytotoxicity and contributes insignificant interplay with CYP450 isozymes. So, the formulation is taken into account to be secure for its therapeutic administration with none potential drug interplay involving CYP 450 isozymes.

Complete assessment of hepatotoxicity related to conventional Indian Ayurvedic herbs

With rising antipathy towards standard prescribed drugs as a result of worry of adversarial occasions, the overall and affected person populations have been more and more utilizing complementary and various drugs (CAMs) for managing acute and continual illnesses. The final false impression is that pure herbal-based preparations are devoid of toxicity, and therefore short- and long-term use stay justified amongst individuals in addition to the CAM practitioners who prescribe these medicines. On this regard, Ayurvedic natural drugs have turn out to be one of the utilized within the East, particularly the Indian sub-continent, with growing use within the West. Latest well-performed observational research have confirmed the hepatotoxic potential of Ayurvedic medicine.
Toxicity stems from direct results or from oblique results by way of natural metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic medicine with different prescription medicines, and contamination as a result of poor manufacturing practices. On this exhaustive assessment, we current particulars on their hepatotoxic potential, talk about the mechanisms, medical presentation, liver histology and affected person outcomes of sure generally used Ayurvedic herbs which can function a information financial institution for physicians caring for liver illness sufferers, to assist early identification and remedy of those that current with CAM-induced liver damage.
 Metabolite profiling and evaluation of CYP450 interaction potential of 'Trimada'- An Ayurvedic formulation
Metabolite profiling and evaluation of CYP450 interaction potential of ‘Trimada’- An Ayurvedic formulation

Differential impact of Ayurvedic nootropics on C. elegans fashions of Parkinson’s illness

Background: Globally, there may be elevated incidence of Parkinson’s Illness (PD), which is the second most typical age-related neurodegenerative illness. The presently obtainable PD-therapeutics present solely symptomatic reduction. Thus, there may be an pressing want to plot an efficient and secure remedy technique for PD. The holistic method of Ayurveda is usually a potential efficient technique for treating PD. The combination of various drugs programs, comparable to trendy bio-medicine and Ayurveda might be an efficient technique for remedy of complicated illnesses, together with PD.
Goal: This examine aimed to judge the neuroprotective mechanism of six Ayurvedic nootropics which can be generally used to deal with PD.
Materials and strategies: Six Ayurvedic herbs, particularly Mucuna pruriens (MP), Bacopa monnieri (BM), Withania somnifera (WS), Centella asiatica (CA), Sida cordifolia (SC), and Celastrus paniculatus (CP), had been chosen after session with Ayurvedic students and physicians. The mode of motion of methanolic natural extracts was evaluated utilizing the Caenorhabditis elegans BZ555 and NL5901 strains, which can be utilized to mannequin the 2 major hallmarks of PD, particularly degeneration of dopaminergic neurons and aggregation of α-synuclein protein.

Anti-Integrin alpha antibody

STJ93729 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alphaE.

Anti-Integrin alpha antibody

STJ93730 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alphaV.

Anti-Integrin alpha antibody

STJ96825 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alphaD.

Anti-Integrin alpha antibody

STJ97273 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alphaL.

Anti-Integrin alpha antibody

STJ97283 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alpha2.

Anti-Integrin alpha antibody

STJ97284 200 µl
EUR 197
Description: Integrin alpha5 is a protein encoded by the ITGA5 gene which is approximately 114,5 kDa. Integrin alpha5 is localised to the cell membrane and is involved in the MAPK-Erk pathway, apoptotic pathways, integrin pathway, focal adhesion and blood-brain barrier and immune cell transmigration. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signalling. Integrin alpha5 is expressed in the liver, lung, nervous system, bone marrow and blood. Mutations in the ITGA5 gene may result in colon carcinoma and congenital epulis STJ97284 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Integrin alpha5 protein.

Anti-Integrin alpha antibody

STJ97285 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alpha6.

Anti-Integrin alpha antibody

STJ97657 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alpha3.

Anti-Integrin alpha antibody

STJ98181 100 µl
EUR 234
Description: Mouse monoclonal to Integrin alpha5.

Anti-Integrin alpha antibody

STJ98510 100 µl
EUR 234
Description: Mouse monoclonal to Integrin alpha5.

Anti-Integrin alpha antibody

STJ98511 100 µl
EUR 234
Description: Mouse monoclonal to Integrin alpha6.

Anti-Integrin alpha antibody

STJ98709 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alpha1.

Anti-Integrin alpha antibody

STJ98737 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alphaX.

Anti-Integrin alpha antibody

STJ98984 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alphaE.

Anti-Integrin alpha antibody

STJ96613 200 µl
EUR 197
Description: Rabbit polyclonal to Integrin alpha4.

anti-Integrin alpha 6

YF-PA12761 50 ul
EUR 363
Description: Mouse polyclonal to Integrin alpha 6

anti-Integrin alpha 6

YF-PA12762 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin alpha 6

anti-Integrin alpha 1

YF-PA12784 50 ug
EUR 363
Description: Mouse polyclonal to Integrin alpha 1

anti-Integrin alpha 4

YF-PA12785 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin alpha 4

anti-Integrin alpha V

YF-PA12786 50 ul
EUR 363
Description: Mouse polyclonal to Integrin alpha V

anti-Integrin alpha V

YF-PA12787 50 ug
EUR 363
Description: Mouse polyclonal to Integrin alpha V

anti-Integrin alpha V

YF-PA12788 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin alpha V

anti-Integrin alpha 6

YF-PA24004 50 ul
EUR 334
Description: Mouse polyclonal to Integrin alpha 6

anti-Integrin alpha 1

YF-PA24011 50 ul
EUR 334
Description: Mouse polyclonal to Integrin alpha 1

anti-Integrin alpha 4

YF-PA24013 50 ul
EUR 334
Description: Mouse polyclonal to Integrin alpha 4

anti-Integrin alpha 9

YF-PA24015 50 ul
EUR 334
Description: Mouse polyclonal to Integrin alpha 9

anti-Integrin alpha E

YF-PA24017 50 ul
EUR 334
Description: Mouse polyclonal to Integrin alpha E

anti- Integrin alpha-1 antibody

FNab04343 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: integrin, alpha 1
  • Uniprot ID: P56199
  • Research Area: Stem Cells, Immunology, Cardiovascular
Description: Antibody raised against Integrin alpha-1

anti- Integrin alpha-3 antibody

FNab04344 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IF: 1:20-1:200
  • Immunogen: integrin, alpha 3
  • Uniprot ID: P26006
  • Gene ID: 3675
  • Research Area: Immunology
Description: Antibody raised against Integrin alpha-3

anti- Integrin alpha-3 antibody

FNab04345 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: integrin, alpha 3
  • Uniprot ID: P26006
  • Gene ID: 3675
  • Research Area: Immunology
Description: Antibody raised against Integrin alpha-3

anti- Integrin alpha-4 antibody

FNab04346 100µg
EUR 505.25
  • Recommended dilution: WB: 1500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: integrin, alpha 4
  • Uniprot ID: P13612
  • Gene ID: 3676
  • Research Area: Stem Cells, Immunology, Cardiovascular
Description: Antibody raised against Integrin alpha-4

anti- Integrin alpha-5 antibody

FNab04347 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: integrin, alpha 5
  • Uniprot ID: P08648
  • Research Area: Stem Cells, Immunology, Cardiovascular, Cancer
Description: Antibody raised against Integrin alpha-5

anti- Integrin alpha-9 antibody

FNab04348 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IF: 1:10-1:100
  • Immunogen: integrin, alpha 9
  • Uniprot ID: Q13797
  • Research Area: Immunology, Cardiovascular
Description: Antibody raised against Integrin alpha-9

Anti-Integrin alpha-1 antibody

PAab04343 100 ug
EUR 412

Anti-Integrin alpha-3 antibody

PAab04344 100 ug
EUR 412

Anti-Integrin alpha-4 antibody

PAab04346 100 ug
EUR 355

Anti-Integrin alpha-5 antibody

PAab04347 100 ug
EUR 386

Anti-Integrin alpha-9 antibody

PAab04348 100 ug
EUR 355

Anti-Integrin alpha 6 (4C1)

YF-MA13842 100 ug
EUR 363
Description: Mouse monoclonal to Integrin alpha 6

Anti-Integrin alpha 1 (4G11)

YF-MA13866 100 ug
EUR 363
Description: Mouse monoclonal to Integrin alpha 1

Anti-Integrin alpha 4 (2G10)

YF-MA13867 100 ug
EUR 363
Description: Mouse monoclonal to Integrin alpha 4

Anti-Integrin alpha 9 (3E4)

YF-MA13869 100 ug
EUR 363
Description: Mouse monoclonal to Integrin alpha 9

Anti-Integrin alpha E (6B8)

YF-MA13870 100 ug
EUR 363
Description: Mouse monoclonal to Integrin alpha E

Anti-Integrin alpha 4 (2C11)

YF-MA10493 100 ug
EUR 363
Description: Mouse monoclonal to Integrin alpha 4

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

anti- CD11a/Integrin alpha-L antibody

FNab01409 100µg
EUR 585
  • Recommended dilution: IHC: 1:20-1:500
  • Immunogen: integrin, alpha L
  • Uniprot ID: P20701
  • Research Area: Cancer, Immunology, Signal Transduction
Description: Antibody raised against CD11a/Integrin alpha-L

anti- CD11B/Integrin alpha M antibody

FNab01410 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:50-1:200
  • Immunogen: integrin, alpha M(complement component 3 receptor 3 subunit)
  • Uniprot ID: P11215
  • Research Area: Neuroscience, Cancer, Immunology
Description: Antibody raised against CD11B/Integrin alpha M

anti- CD11B/Integrin alpha M antibody

FNab01411 100µg
EUR 585
  • Recommended dilution: IHC: 1:500-1:2000
  • Immunogen: integrin, alpha M(complement component 3 receptor 3 subunit)
  • Uniprot ID: P11215
  • Research Area: Neuroscience, Cancer, Immunology
Description: Antibody raised against CD11B/Integrin alpha M

anti- CD11c/Integrin alpha X antibody

FNab01412 100µg
EUR 505.25
  • Recommended dilution: WB:1:200-1:2000
  • IHC:1:50-1:200
  • Immunogen: integrin, alpha X(complement component 3 receptor 4 subunit)
  • Uniprot ID: P20702
  • Research Area: Cancer, Immunology
Description: Antibody raised against CD11c/Integrin alpha X

anti- CD11c/Integrin alpha X antibody

FNab01413 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:100-1:400
  • Immunogen: integrin, alpha X(complement component 3 receptor 4 subunit)
  • Uniprot ID: P20702
  • Research Area: Cancer, Immunology
Description: Antibody raised against CD11c/Integrin alpha X

anti- CD11d/Integrin alpha D antibody

FNab01414 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: integrin, alpha D
  • Uniprot ID: Q13349
  • Research Area: Immunology
Description: Antibody raised against CD11d/Integrin alpha D

anti- CD41/Integrin alpha 2b antibody

FNab01478 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:10000IP:1:1000-1:10000IHC: 1:20-1:200
  • Immunogen: integrin, alpha 2b(platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Uniprot ID: P08514
  • Gene ID: 958
  • Research Area: Stem Cells, Immunology, Cardiovascular
Description: Antibody raised against CD41/Integrin alpha 2b

anti- Integrin alpha 6X1A-Specific antibody

FNab04341 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: integrin, alpha 6
  • Uniprot ID: P23229
  • Research Area: Stem Cells, Immunology
Description: Antibody raised against Integrin alpha 6X1A-Specific

Anti-Integrin alpha 6/ITGA6 Antibody

A01693 100ug/vial
EUR 294

Anti-Integrin alpha 5/ITGA5 Antibody

A01911 100ug/vial
EUR 334

Anti-Integrin alpha 3/ITGA3 Antibody

A02902 100ug/vial
EUR 334

Anti-Integrin alpha 1/ITGA1 Antibody

A03829 100ug/vial
EUR 334

Anti-Integrin alpha 5/ITGA5 Antibody

PB9254 100ug/vial
EUR 294

Anti-Integrin alpha 4/ITGA4 Antibody

PB9648 100ug/vial
EUR 334

Anti-CD11B/Integrin alpha M antibody

PAab01410 100 ug
EUR 412

Anti-CD11B/Integrin alpha M antibody

PAab01411 100 ug
EUR 412

Anti-CD11c/Integrin alpha X antibody

PAab01412 100 ug
EUR 355

Anti-CD11d/Integrin alpha D antibody

PAab01414 100 ug
EUR 412

Anti-CD41/Integrin alpha 2b antibody

PAab01478 100 ug
EUR 412

Anti-Integrin alpha 6X1A-Specific antibody

PAab04341 100 ug
EUR 386

Anti-Integrin alpha 6X1B-Specific antibody

PAab04342 100 ug
EUR 355

Anti-Integrin alpha 1/ITGA1 Antibody

PA1045 100ug/vial
EUR 294

Anti-Integrin alpha 1/ITGA1 Antibody

PA1045-1 100ug/vial
EUR 334

Anti-Integrin alpha 4/ITGA4 Antibody

PA1046 100ug/vial
EUR 334

Anti-Integrin alpha V/ITGAV Antibody

PA1405 100ug/vial
EUR 334

Anti-Integrin alpha 3/ITGA3 Antibody

PA1621 100ug/vial
EUR 334

Anti-Integrin alpha 3/ITGA3 Antibody

PA1621-1 100ug/vial
EUR 334

Anti-Integrin alpha E/ITGAE Antibody

PA1622 100ug/vial
EUR 334

Anti-Integrin alpha 6/ITGA6 Antibody

PA2210 100ug/vial
EUR 334

Anti-Integrin alpha 11 (mouse) antibody

STJ72472 100 µg
EUR 359

Anti-Phospho-Integrin alpha (S1027) antibody

STJ91315 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Integrin alpha4 (S1027).

Anti-CD11A / integrin alpha L antibody

STJ71969 100 µg
EUR 359

Anti-Alpha v Beta Integrin antibody

STJ16100153 1 mL
EUR 720

Alpha V Beta 5 Integrin, Peptide Aptamer, Biotinylated

AP-301-B 1 mg Ask for price

Alpha V Beta 5 Integrin, Peptide Aptamer, unlabeled

AP-301-U 5 mg Ask for price

Anti-Integrin alpha 4 (Natalizumab), Human IgG4 Antibody

A1444-200
EUR 778

Rabbit Anti-Human Fodrin-alpha (spectrin-alpha) antiserum

FOD11-S 100 ul
EUR 457

Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled

AP-301-F 1 mg Ask for price

Anti-CD41/Integrin alpha 2b/ITGA2B Antibody

A01102 100ug/vial
EUR 334

Anti-CD41/Integrin alpha 2b/ITGA2B Antibody

PB9647 100ug/vial
EUR 334

Anti-Integrin alpha 4 Rabbit Monoclonal Antibody

M00468 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha 4 Antibody. Validated in WB and tested in Human.

Anti-Integrin alpha V Rabbit Monoclonal Antibody

M01561 100ug/vial
EUR 397
Description: Anti-Integrin alpha V Rabbit Monoclonal Antibody tested for IP, IF, IHC, ICC, WB in Human, Mouse, Rat

Anti-Integrin alpha V Rabbit Monoclonal Antibody

M01561-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha V Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Integrin alpha 6 Rabbit Monoclonal Antibody

M01693 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha 6 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Integrin alpha 5 Rabbit Monoclonal Antibody

M01911 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha 5 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-Integrin alpha 2 Rabbit Monoclonal Antibody

M01933 100ug/vial
EUR 397
Description: Anti-Integrin alpha 2 Rabbit Monoclonal Antibody tested for Flow Cytometry, IP, IF, ICC, IHC, WB in Human, Mouse, Rat

Anti-Integrin alpha E Rabbit Monoclonal Antibody

M07091 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha E Antibody. Validated in IHC and tested in Human.

Anti-Cleaved-Integrin alpha HC (F42) antibody

STJ90087 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Integrin alpha5 HC (F42).

Anti-Cleaved-Integrin alpha LC (E895) antibody

STJ90088 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Integrin alpha5 LC (E895).

Anti-Cleaved-Integrin alpha LC (E942) antibody

STJ90089 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Integrin alpha6 LC (E942).

Anti-Cleaved-Integrin alpha LC (E959) antibody

STJ90090 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Integrin alpha7 LC (E959).

Anti-Cleaved-Integrin alpha HC (K889) antibody

STJ90091 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Integrin alphaV HC (K889).

Human Integrin alpha-2 (ITGA2)

1-CSB-YP011864HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 21.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Integrin alpha-2(ITGA2),partial expressed in Yeast

Human Integrin alpha-IIb (ITGA2B)

1-CSB-YP011865HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 29 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Integrin alpha-IIb(ITGA2B),partial expressed in Yeast

Human Integrin alpha-V (ITGAV)

1-CSB-YP011877HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 19.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Integrin alpha-V(ITGAV),partial expressed in Yeast

Human Integrin alpha-2 (ITGA2)

1-CSB-EP011864HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 35.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Integrin alpha-2(ITGA2) ,partial expressed in E.coli

Human Integrin alpha-IIb (ITGA2B)

1-CSB-EP011865HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 43 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Integrin alpha-IIb(ITGA2B),partial expressed in E.coli

Recombinant human Integrin alpha-10

P1321 100ug Ask for price
  • Uniprot ID: O75578
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Integrin alpha-10

Recombinant human Integrin alpha-E

P1608 100ug Ask for price
  • Uniprot ID: P38570
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Integrin alpha-E

Rabbit Anti-Human Glutathione Transferase alpha (GST-alpha) antiserum

GSTA12-S 100 ul
EUR 457

Monoclonal Anti-Human alpha-Tubulin IgG

TUBA12-M 100 ul
EUR 482

Rabbit Anti-Human alpha-Tubulin IgG

TUBA13-A 100 ul
EUR 482

Rabbit Anti-Human Fodrin-alpha (spectrin-alpha) IgG, aff pure

FOD11-A 100 ug
EUR 482

Rabbit Anti-Human Estrogen receptor alpha (ER-alpha) peptide IgG

ERA12-A 100 ug
EUR 482

Chicken Anti-Human alpha 1 anti-trypsin IgG/Y

A1AT12-A 100 ul
EUR 482

Integrin alpha V Antibody

AF5152 200ul
EUR 304
Description: Integrin αV Antibody detects endogenous levels of total Integrin αV.

Integrin alpha E Antibody

AF5155 200ul
EUR 304
Description: Integrin αE Antibody detects endogenous levels of total Integrin αE.

Integrin alpha-1 Antibody

abx234343-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Integrin alpha-3 Antibody

abx234344-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Integrin alpha-3 Antibody

abx234345-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Integrin alpha-4 Antibody

abx234346-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Integrin alpha-5 Antibody

abx234347-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Integrin alpha-9 Antibody

abx234348-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Integrin alpha 7 antibody

70R-49933 100 ul
EUR 244
Description: Purified Polyclonal Integrin alpha 7 antibody

Integrin Alpha 8 antibody

70R-6849 50 ug
EUR 467
Description: Rabbit polyclonal Integrin Alpha 8 antibody raised against the N terminal of ITGA8

Integrin alpha 5 Antibody

49269-100ul 100ul
EUR 333

Integrin alpha 5 Antibody

49269-50ul 50ul
EUR 239

Integrin alpha 4 Antibody

49543-100ul 100ul
EUR 333
Outcomes: All six natural extracts exhibited neuroprotective impact. The extracts of BM and MP exhibited most safety in opposition to 1-methyl-4-phenylpyridinium iodide (MPP+ iodide)-induced dopaminergic neurodegeneration within the BZ555 pressure. Moreover, the natural extracts, besides CA extract, inhibited the aggregation of heterologously expressed human α-synuclein within the NL5901 pressure.

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