July 16, 2024

Metabolite profiling and evaluation of CYP450 interaction potential of ‘Trimada’- An Ayurvedic formulation

Ethnopharmacological relevance: Trimada is well-known polyherbal Ayurvedic formulation utilized in Indian Conventional drugs since historic occasions. It consisted of three inebriant herbs together with “Chitraka” (Plumbago zeylanica Linn. Household- Plumabaginaceae), “Musta” (Cyperus rotundus Linn. Household- Cyperaceae) and Vidanga (Embelia ribes Burm. F. Household- Myrsinaceae) in equal ratios as talked about in Ayurveda. Trimada is historically used to extend the functioning of the digestive system and metabolism. Together with these, it additionally assists within the discount of ldl cholesterol in addition to reduces abdomen aches and chest ache.
Purpose of the examine: This examine is aimed to determine the metabolites current on this polyherbal formulation. Additional, the cytotoxicity and interplay potential of the formulation and particular person herbs with Cytochrome P450 isozymes (CYP3A4, 2D6, 2C9, 1A2) was evaluated by MTT assay and CYP450 enzyme inhibition. The focus of heavy metals was additionally decided.
Materials and strategies: Extremely-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS) evaluation was carried out to detect and determine the phytoconstituents within the formulation. Cytotoxicity of the formulation was evaluated by MTT assay. CYP450 enzyme interplay potential of the person herbs and the Trimada formulation was carried out by way of CYP-CO assay and fluorometric excessive throughput screening (HTS) assay for particular person isozymes. The content material of heavy metallic within the formulation was quantified by Atomic Absorption Spectroscopy.
Outcomes: Trimada formulation exhibited decrease cytotoxicity to human liver carcinoma cell line (HepG2). CYP-CO assay revealed that the interplay potential of particular person herbs and Trimada on the liver microsomes was discovered to be lesser than the usual inhibitor ketoconazole. Particular person herbs and Trimada formulation displayed increased IC50 values than the respective commonplace inhibitors within the fluorimetric assay. UPLC-QTOF-MS evaluation confirmed the presence of plenty of lively phytoconstituents together with sesquiterpenes, phenolic acids, benzoquinones, triterpenes and flavonoids. The heavy metallic focus within the conventional medicinal natural formulation was discovered inside the accredited restrict.
Conclusions: This examine steered that the person herbs and Trimada formulation exhibited low cytotoxicity and contributes insignificant interplay with CYP450 isozymes. So, the formulation is taken into account to be secure for its therapeutic administration with none potential drug interplay involving CYP 450 isozymes.

Complete assessment of hepatotoxicity related to conventional Indian Ayurvedic herbs

With rising antipathy towards standard prescribed drugs as a result of worry of adversarial occasions, the overall and affected person populations have been more and more utilizing complementary and various drugs (CAMs) for managing acute and continual illnesses. The final false impression is that pure herbal-based preparations are devoid of toxicity, and therefore short- and long-term use stay justified amongst individuals in addition to the CAM practitioners who prescribe these medicines. On this regard, Ayurvedic natural drugs have turn out to be one of the utilized within the East, particularly the Indian sub-continent, with growing use within the West. Latest well-performed observational research have confirmed the hepatotoxic potential of Ayurvedic medicine.
Toxicity stems from direct results or from oblique results by way of natural metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic medicine with different prescription medicines, and contamination as a result of poor manufacturing practices. On this exhaustive assessment, we current particulars on their hepatotoxic potential, talk about the mechanisms, medical presentation, liver histology and affected person outcomes of sure generally used Ayurvedic herbs which can function a information financial institution for physicians caring for liver illness sufferers, to assist early identification and remedy of those that current with CAM-induced liver damage.
 Metabolite profiling and evaluation of CYP450 interaction potential of 'Trimada'- An Ayurvedic formulation
Metabolite profiling and evaluation of CYP450 interaction potential of ‘Trimada’- An Ayurvedic formulation

Differential impact of Ayurvedic nootropics on C. elegans fashions of Parkinson’s illness

Background: Globally, there may be elevated incidence of Parkinson’s Illness (PD), which is the second most typical age-related neurodegenerative illness. The presently obtainable PD-therapeutics present solely symptomatic reduction. Thus, there may be an pressing want to plot an efficient and secure remedy technique for PD. The holistic method of Ayurveda is usually a potential efficient technique for treating PD. The combination of various drugs programs, comparable to trendy bio-medicine and Ayurveda might be an efficient technique for remedy of complicated illnesses, together with PD.
Goal: This examine aimed to judge the neuroprotective mechanism of six Ayurvedic nootropics which can be generally used to deal with PD.
Materials and strategies: Six Ayurvedic herbs, particularly Mucuna pruriens (MP), Bacopa monnieri (BM), Withania somnifera (WS), Centella asiatica (CA), Sida cordifolia (SC), and Celastrus paniculatus (CP), had been chosen after session with Ayurvedic students and physicians. The mode of motion of methanolic natural extracts was evaluated utilizing the Caenorhabditis elegans BZ555 and NL5901 strains, which can be utilized to mannequin the 2 major hallmarks of PD, particularly degeneration of dopaminergic neurons and aggregation of α-synuclein protein.

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1

MBS212234-5x02mg 5x0.2mg
EUR 2070

MOUSE ANTI HUMAN INTEGRIN ALPHA V BETA 5

MBS211733-01mg 0.1mg
EUR 1240

MOUSE ANTI HUMAN INTEGRIN ALPHA V BETA 5

MBS211733-5x01mg 5x0.1mg
EUR 5410

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1

MBS215105-0025mg 0.025mg
EUR 210

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1

MBS215105-5x0025mg 5x0.025mg
EUR 765

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1

MBS213386-01mg 0.1mg
EUR 920

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1

MBS213386-5x01mg 5x0.1mg
EUR 3965

Human Integrin alpha-M

E01A5419 96T
EUR 700
Description: ELISA

Human Integrin alpha-X

E01A5432 96T
EUR 700
Description: ELISA

Human Anti Integrin alpha 4 (Natalizumab Biosimilar)

MBS225705-02mg 0.2mg
EUR 720

Human Anti Integrin alpha 4 (Natalizumab Biosimilar)

MBS225705-5x02mg 5x0.2mg
EUR 3165

Human Integrin alpha-2 (ITGA2)

1-CSB-YP011864HU
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Description: Recombinant Human Integrin alpha-2(ITGA2),partial expressed in Yeast

Human Integrin alpha-2 (ITGA2)

1-CSB-EP011864HU
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Description: Recombinant Human Integrin alpha-2(ITGA2) ,partial expressed in E.coli

Human Integrin alpha-V (ITGAV)

1-CSB-YP011877HU
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Description: Recombinant Human Integrin alpha-V(ITGAV),partial expressed in Yeast

Anti-Human Integrin alpha 2 Antibody

101-M515 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 3 Antibody

101-M516 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 4 Antibody

101-M517 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 5 Antibody

101-M518 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 6 Antibody

101-M519 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha M Antibody

101-M520 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha V Antibody

101-M521 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha X Antibody

101-M522 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 6 Antibody

101-M797 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Recombinant human Integrin alpha-10

P1321 100ug Ask for price
Description: Recombinant protein for human Integrin alpha-10

Recombinant Human Integrin alpha-2

MBS961599-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human Integrin alpha-2

MBS961599-002mgYeast 0.02mg(Yeast)
EUR 270

Recombinant Human Integrin alpha-2

MBS961599-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human Integrin alpha-2

MBS961599-01mgYeast 0.1mg(Yeast)
EUR 450

Recombinant Human Integrin alpha-2

MBS961599-05mgYeast 0.5mg(Yeast)
EUR 1065

Human Integrin alpha-IIb (ITGA2B)

1-CSB-YP011865HU
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Description: Recombinant Human Integrin alpha-IIb(ITGA2B),partial expressed in Yeast

Human Integrin alpha-IIb (ITGA2B)

1-CSB-EP011865HU
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Description: Recombinant Human Integrin alpha-IIb(ITGA2B),partial expressed in E.coli

Human Integrin Alpha 2β1 ELISA kit

E01A5231 96T
EUR 700
Description: ELISA

anti- Integrin alpha-1 antibody

FNab04343 100µg
EUR 702
Description: Antibody raised against Integrin alpha-1

anti- Integrin alpha-3 antibody

FNab04344 100µg
EUR 702
Description: Antibody raised against Integrin alpha-3

anti- Integrin alpha-3 antibody

FNab04345 100µg
EUR 702
Description: Antibody raised against Integrin alpha-3

anti- Integrin alpha-4 antibody

FNab04346 100µg
EUR 606.3
Description: Antibody raised against Integrin alpha-4

anti- Integrin alpha-5 antibody

FNab04347 100µg
EUR 658.5
Description: Antibody raised against Integrin alpha-5

anti- Integrin alpha-9 antibody

FNab04348 100µg
EUR 606.3
Description: Antibody raised against Integrin alpha-9

Mouse anti Integrin alpha 3B + alpha 6B

MBS570088-01mg 0.1mg
EUR 515

Mouse anti Integrin alpha 3B + alpha 6B

MBS570088-5x01mg 5x0.1mg
EUR 2165

Mouse anti Integrin alpha 3A

MBS570064-01mg 0.1mg
EUR 515

Mouse anti Integrin alpha 3A

MBS570064-5x01mg 5x0.1mg
EUR 2165

Mouse anti Integrin alpha 3B

MBS570101-01mg 0.1mg
EUR 515

Mouse anti Integrin alpha 3B

MBS570101-5x01mg 5x0.1mg
EUR 2165

Mouse anti Integrin alpha 3A

MBS570166-01mg 0.1mg
EUR 515

Mouse anti Integrin alpha 3A

MBS570166-5x01mg 5x0.1mg
EUR 2165

Mouse anti Integrin alpha 6B

MBS570179-01mg 0.1mg
EUR 515

Mouse anti Integrin alpha 6B

MBS570179-5x01mg 5x0.1mg
EUR 2165

Human Integrin alpha-4 ELISA Kit

EK3660 96 tests
EUR 599

Human Integrin alpha-5 ELISA Kit

EK4913 96 tests
EUR 739

Human Integrin alpha-9 ELISA Kit

EK4984 96 tests
EUR 739

Human Integrin alpha-4 ELISA Kit

MBS9427494-5x96Tests 5x96Tests
EUR 2820

Human Integrin alpha-4 ELISA Kit

MBS9427494-96Tests 96Tests
EUR 615

Human Integrin alpha-9 ELISA Kit

MBS764614-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Integrin alpha-9 ELISA Kit

MBS764614-48StripWells 48-Strip-Wells
EUR 340

Human Integrin alpha-9 ELISA Kit

MBS764614-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Integrin alpha-9 ELISA Kit

MBS764614-96StripWells 96-Strip-Wells
EUR 455

Human Integrin alpha-5 ELISA Kit

MBS761812-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Integrin alpha-5 ELISA Kit

MBS761812-48StripWells 48-Strip-Wells
EUR 340

Human Integrin alpha-5 ELISA Kit

MBS761812-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Integrin alpha-5 ELISA Kit

MBS761812-96StripWells 96-Strip-Wells
EUR 455

Human Integrin alpha-4 ELISA Kit

MBS761081-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Integrin alpha-4 ELISA Kit

MBS761081-48StripWells 48-Strip-Wells
EUR 340

Human Integrin alpha-4 ELISA Kit

MBS761081-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Integrin alpha-4 ELISA Kit

MBS761081-96StripWells 96-Strip-Wells
EUR 455

Human Integrin alpha-5 ELISA Kit

MBS2882218-10x96StripWells 10x96-Strip-Wells
EUR 4630

Human Integrin alpha-5 ELISA Kit

MBS2882218-48StripWells 48-Strip-Wells
EUR 440

Human Integrin alpha-5 ELISA Kit

MBS2882218-5x96StripWells 5x96-Strip-Wells
EUR 2480

Human Integrin alpha-5 ELISA Kit

MBS2882218-96StripWells 96-Strip-Wells
EUR 580

Human Integrin alpha-9 ELISA Kit

MBS2885865-10x96StripWells 10x96-Strip-Wells
EUR 4630

Human Integrin alpha-9 ELISA Kit

MBS2885865-48StripWells 48-Strip-Wells
EUR 440

Human Integrin alpha-9 ELISA Kit

MBS2885865-5x96StripWells 5x96-Strip-Wells
EUR 2480

Human Integrin alpha-9 ELISA Kit

MBS2885865-96StripWells 96-Strip-Wells
EUR 580

Human Integrin alpha-4 ELISA Kit

MBS2883237-10x96StripWells 10x96-Strip-Wells
EUR 4080

Human Integrin alpha-4 ELISA Kit

MBS2883237-48StripWells 48-Strip-Wells
EUR 390

Human Integrin alpha-4 ELISA Kit

MBS2883237-5x96StripWells 5x96-Strip-Wells
EUR 2220

Human Integrin alpha-4 ELISA Kit

MBS2883237-96StripWells 96-Strip-Wells
EUR 520

Human Integrin alpha-5 ELISA Kit

MBS9428739-5x96Tests 5x96Tests
EUR 3385

Human Integrin alpha-5 ELISA Kit

MBS9428739-96Tests 96Tests
EUR 735

Human Integrin alpha-9 ELISA Kit

MBS9428810-5x96Tests 5x96Tests
EUR 3385

Human Integrin alpha-9 ELISA Kit

MBS9428810-96Tests 96Tests
EUR 735

Recombinant human Integrin alpha-E

P1608 100ug Ask for price
Description: Recombinant protein for human Integrin alpha-E

Recombinant Human Integrin alpha-V

MBS9422356-002mg 0.02mg
EUR 320

Recombinant Human Integrin alpha-V

MBS9422356-01mg 0.1mg
EUR 540

Recombinant Human Integrin alpha-V

MBS9422356-05mg 0.5mg
EUR 1360

Recombinant Human Integrin alpha-V

MBS9422356-5x05mg 5x0.5mg
EUR 5965

Mouse Anti Human Integrin Alpha 9 Beta 1 Monoclonal Antibody

CABT-49624MH 0.2 mg
EUR 920.4

Mouse Anti Human Integrin Alpha 9 Beta 1 Monoclonal Antibody

CABT-49625MH 0.1 mg
EUR 1132.8

Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody

CABT-49626MH 0.1 mg
EUR 1650

Recombinant Human Integrin alpha-IIb

MBS956218-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human Integrin alpha-IIb

MBS956218-002mgYeast 0.02mg(Yeast)
EUR 270

Recombinant Human Integrin alpha-IIb

MBS956218-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human Integrin alpha-IIb

MBS956218-01mgYeast 0.1mg(Yeast)
EUR 450

Recombinant Human Integrin alpha-IIb

MBS956218-05mgYeast 0.5mg(Yeast)
EUR 1065

Human Integrin Alpha 6 ELISA kit

E01A5374 96T
EUR 700
Description: ELISA

Human Integrin alpha 2b Elisa kit

E01A5446 96T
EUR 700
Description: ELISA

Human Integrin Alpha 5 ELISA Kit

E01A5456 96T
EUR 700
Description: ELISA

Human Integrin Alpha 6 ELISA kit

E01I0416-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Integrin Alpha 6 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Integrin Alpha 6 ELISA kit

E01I0416-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Integrin Alpha 6 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Integrin Alpha 6 ELISA kit

E01I0416-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Integrin Alpha 6 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Integrin Alpha 2 ELISA Kit

MBS095761-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Integrin Alpha 2 ELISA Kit

MBS095761-48StripWells 48-Strip-Wells
EUR 550

Human Integrin Alpha 2 ELISA Kit

MBS095761-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Integrin Alpha 2 ELISA Kit

MBS095761-96StripWells 96-Strip-Wells
EUR 765

Human Integrin Alpha 3 ELISA Kit

MBS089458-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Integrin Alpha 3 ELISA Kit

MBS089458-48StripWells 48-Strip-Wells
EUR 550

Human Integrin Alpha 3 ELISA Kit

MBS089458-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Integrin Alpha 3 ELISA Kit

MBS089458-96StripWells 96-Strip-Wells
EUR 765

Human Integrin Alpha 5 ELISA Kit

MBS094108-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Integrin Alpha 5 ELISA Kit

MBS094108-48StripWells 48-Strip-Wells
EUR 550

Human Integrin Alpha 5 ELISA Kit

MBS094108-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Integrin Alpha 5 ELISA Kit

MBS094108-96StripWells 96-Strip-Wells
EUR 765

Human Integrin Alpha M ELISA Kit

MBS053160-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Integrin Alpha M ELISA Kit

MBS053160-48StripWells 48-Strip-Wells
EUR 550

Human Integrin Alpha M ELISA Kit

MBS053160-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Integrin Alpha M ELISA Kit

MBS053160-96StripWells 96-Strip-Wells
EUR 765

Human Integrin Alpha V ELISA Kit

MBS064086-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Integrin Alpha V ELISA Kit

MBS064086-48StripWells 48-Strip-Wells
EUR 550

Human Integrin Alpha V ELISA Kit

MBS064086-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Integrin Alpha V ELISA Kit

MBS064086-96StripWells 96-Strip-Wells
EUR 765

Human Integrin Alpha 1 ELISA Kit

MBS067363-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Integrin Alpha 1 ELISA Kit

MBS067363-48StripWells 48-Strip-Wells
EUR 550

Human Integrin Alpha 1 ELISA Kit

MBS067363-5x96StripWells 5x96-Strip-Wells
EUR 3420
Outcomes: All six natural extracts exhibited neuroprotective impact. The extracts of BM and MP exhibited most safety in opposition to 1-methyl-4-phenylpyridinium iodide (MPP+ iodide)-induced dopaminergic neurodegeneration within the BZ555 pressure. Moreover, the natural extracts, besides CA extract, inhibited the aggregation of heterologously expressed human α-synuclein within the NL5901 pressure.

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