India, with a wealthy heritage of floral variety, is well-known for its medicinal plant wealth and is the biggest producer of medicinal herbs on the earth. Ethnobiological Survey of Ministry of Setting and Forests (MOEF) may determine 8000 plant species utilized in varied programs of medication with roughly 25,000 efficient natural formulations. The intensive consumption to fulfill demand-supply ratio exerts a heavy pressure on the present assets. This subsequently led to the adulteration and substitution of medicinal vegetation with look-alike species. The buyer’s religion on natural medication is within the section of decline because of the extremities in adulteration/substitution and ensuing penalties.
It’s crucial to deliver forth universally acceptable commonplace instruments to authenticate uncooked medication earlier than being processed additional into formulations. An unlimited array of methods comparable to bodily, chemical (analytical), biochemical, anatomical, organoleptic, and just lately emerged DNA primarily based molecular strategies are extensively used for plant species authentication. Lately, DNA barcoding has made outstanding progress within the discipline of medicinal vegetation analysis. DNA metabarcoding is the most recent growth for qualitative analysis of the natural formulations, whereas for quantitative evaluation, mixture of pharmacognostic, pharmacovigilance and analytical strategies are inevitable for authentication. This overview addresses the general strengths and shortcomings of the present in addition to just lately emerged methods in authenticating ayurvedic uncooked medication.
From ayurvedic folks medication to preclinical neurotherapeutic function of a miraculous herb, Tinospora cordifolia
In Ayurveda, the age-old Indian conventional system of medication, well being is taken into account to be achieved as equilibrium of bodily and psychological wellbeing and mind associated illnesses are acknowledged as ‘Vatavyadi’. Rasayana herbs have been primarily used for pharmacological remedy of neurological illnesses and Tinospora cordifolia is among the common Rasayana herbs of Ayurveda. The normal claims of therapeutic exercise of this herb for remedy of fever, diabetes, nervousness, immunodeficiency, reminiscence deficit and psychological issues have been explored by totally different analysis teams utilizing reverse pharmacology and advance technological approaches.
The intention of present overview is to compile and talk about the neurotherapeutic potential of T. cordifolia within the mild of assorted preclinical and scientific research from literature. This overview summarizes the details about totally different extracts of this herb and decoctions used for varied neuro-related issues comparable to neurodegenerative illnesses, neuroinflammation, sleep problems, neural cancers, reminiscence and cognition deficits and psychological issues moreover different potential actions. The overview additionally offers the data of underlying therapeutic mechanism of T. cordifolia and its energetic phytoconstituents.
Poisonous epidermolysis necrosis (TEN) or Lyell syndrome is a probably life-threatening immunological opposed pores and skin illness, which largely happens secondary to the consumption of an offending drug. It generally manifests as a widespread exfoliating bullous lesion in pores and skin and mucous membrane mimicking superficial burns and should end in hypovolemic and/or septic shock. Authors report an uncommon case of Lyell’s syndrome in a 42-year-old girl, secondary to the consumption of Ayurveda medication ‘Vajra Bhasma’ (Diamond Ash) prescribed by an Ayurveda doctor for remedy of her trigeminal neuralgia. After eighth day of steady remedy consumption, she had prodromal sickness and quickly growing exfoliative pores and skin lesion prolonged over 80% of complete physique floor space, respiratory problem, dizziness and anuria. The case was efficiently managed by well timed analysis, enough hydration and administration of immunoglobulins.
Pitfalls and promises of raw drug identification techniques in the ayurvedic industry: an overview
Outcomes of Ayurvedic care in a COVID-19 affected person with hypoxia – A Case Report
This paper studies for the primary time, the outcomes of Ayurvedic intervention in a COVID-19 affected person with extreme hypoxia requiring supportive oxygen remedy. Affected person developed fever, extreme cough, lack of odor, lack of style, nasal block, anorexia, headache, physique ache, chills, and fatigue and was hospitalised when she developed extreme respiratory problem. Later, she examined constructive for COVID-19 by RT PCR. The affected person sought Ayurvedic remedy voluntarily when her SPO2 remained at 80% even after being given oxygen assist.
The affected person was administered Ayurvedic medicines whereas present process oxygen remedy on the hospital. The affected person refused to take Fabiflu really useful by the treating doctor and discontinued different allopathic medication apart from Vitamin C. The affected person confirmed scientific enchancment inside a day of administration of Ayurvedic medicines and was in a position to speak, eat, and sit on the mattress with out respiratory problem and her SPO2 grew to become secure between 95 and 98%.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 14 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 14 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 14 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 7 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 7 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 7 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 8 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 8 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 8 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin 9 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: Galectin 1 is a protein that in humans is encoded by the LGALS1 gene. Galectins belong to a family of related beta-galactoside-binding lectins, also referred to as S-type or S-Lac lectins. Its gene is mapped to 22q12-q13. Galectin 1 was expressed in a subset of slowly dividing subventricular zone astrocytes, which included the neural stem cells. It has been considered as an autocrine negative growth factor that regulates cell proliferation.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-8 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-1 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-4 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-2 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-7 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-3BP in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant human Galectin-3 is a globular 26.0kDa protein containing 250 amino acid residues, but no disulfide bonds.
Within the subsequent two days, she was asymptomatic with out oxygen assist and was discharged from the hospital within the following week. Since weight problems and excessive plasma CRP indicated excessive threat for development to extreme illness, the beneficial outcomes with Ayurvedic remedy on this affected person is important and warrants additional research. Ayurveda care could also be thought-about as first-line cost-effective different for COVID-19 sufferers presenting with symptomatic hypoxia in an integrative setup.
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